Anti-BCL2 Mouse Monoclonal Antibody (CF488A) [clone: 8C8]

Leverandør: Biotium
BNC880005-100EA 2075 NOK
BNC880005-100 BNC880005-500
Anti-BCL2 Mouse Monoclonal Antibody (CF488A) [clone: 8C8]
This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

Type: Primary
Antigen: BCL2
Clonality: Monoclonal
Clone: 8C8
Conjugation: CF488A
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Monkey, Pig
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