Rapamycin ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES
Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12 target). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin induces inhibition of p70s6k, p33cdk2 and p34cdc2. Selectively blocks signaling leading to the activation of p70/85 S6 kinase. Enhances apoptosis. Activator of autophagy both in vitro and in vivo.
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Rapamycin (from Streptomyces hygroscopicus)
Supplier: Apollo Scientific
Macrocyclic triene antibiotic.
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Rapamycin ≥98%, powder
Supplier: MP Biomedicals
Rapamycin binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.
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Rapamycin-LC-Fluorescein
Supplier: AAT BIOQUEST
Rapamycin-LC-Fluorescein is an excellent fluorescent probe to characterize FK506-binding proteins by fluorescence polarization.
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Rapamycin, analytical standard, VETRANAL™, Supelco®
Supplier: Merck
Organic Standard, Rapamycin
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Anti-FK506 Binding Protein 12-Rapamycin Associated Protein 1 Rabbit polyclonal antibody
Supplier: US Biological
Anti-FK506 Binding Protein 12-Rapamycin Associated Protein 1 Rabbit Polyclonal Antibody
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Anti-FK506 Binding Protein 12-Rapamycin Associated Protein 1 Rabbit polyclonal antibody
Supplier: US Biological
Anti-FK506 Binding Protein 12-Rapamycin Associated Protein 1 Rabbit Polyclonal Antibody
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Anti-RICTOR Rabbit Polyclonal Antibody
Supplier: US Biological
Anti-RICTOR Rabbit Polyclonal Antibody
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Anti-RICTOR Rabbit Polyclonal Antibody (FITC (Fluorescein))
Supplier: US Biological
Anti-RICTOR Rabbit Polyclonal Antibody (FITC (Fluorescein))
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Anti-MLST8 Mouse Monoclonal Antibody (HRP (Horseradish Peroxidase)) [clone: 211CT7.1.1]
Supplier: US Biological
Anti-MLST8 Mouse Monoclonal Antibody (HRP (Horseradish Peroxidase)) [clone: 211CT7.1.1]
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Anti-RICTOR Rabbit Polyclonal Antibody
Supplier: US Biological
Anti-RICTOR Rabbit Polyclonal Antibody
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Wortmannin-Rapamycin Conjugate 1 * 1 mg
Supplier: Cayman Chemical
Wortmannin-Rapamycin Conjugate 1 * 1 mg
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Wortmannin-Rapamycin Conjugate 1 * 5 mg
Supplier: Cayman Chemical
Wortmannin-Rapamycin Conjugate 1 * 5 mg
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Anti-RPTOR Mouse Monoclonal Antibody
Supplier: ENZO LIFE SCIENCES
The mTOR (mammalian target of rapamycin) pathway coordinates nutrient signals with growth factor dependent signaling. mTOR is organized in two independent protein complexes, mTORC1 and mTORC2. The mTORC1 complex containing mTOR, GβL/mLST8 and Raptor is sensitive to rapamycin, while the mTORC2 complex containing mTOR, GβL/mLST8, SIN1, and Rictor is rapamycin insensitive.
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Seco Rapamycin (sodium salt) 1 * 1 mg
Supplier: Cayman Chemical
Seco Rapamycin (sodium salt) 1 * 1 mg
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Seco Rapamycin (sodium salt) 1 * 5 mg
Supplier: Cayman Chemical
Seco Rapamycin (sodium salt) 1 * 5 mg
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Wortmannin-Rapamycin Conjugate 1 * 500 µG
Supplier: Cayman Chemical
Wortmannin-Rapamycin Conjugate 1 * 500 µG
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Anti-MLST8 Rabbit Polyclonal Antibody
Supplier: US Biological
Anti-MLST8 Rabbit Polyclonal Antibody
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Anti-MTOR Rabbit Polyclonal Antibody
Supplier: ENZO LIFE SCIENCES
mTOR (FKBP12-rapamycin associated protein (FRAP)) is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. It has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. FKBP12-rapamycin-binding (FRB) domain is a conserved 11kDa region necessary for FKBP12-rapamycin binding. FRB is one of several functional domains of mTOR: HEAT (Huntington elongation factor 1A-protein phosphatase 2A-A subunit-TOR); FAT (FRAP, ATM, TTRAP2); PIKK (PI3-kinase-related kinase); RD (regulatory domain); and FATC (FAT, C terminal).
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Anti-RICTOR Mouse Monoclonal Antibody
Supplier: ENZO LIFE SCIENCES
The mTOR (mammalian target of rapamycin) pathway coordinates nutrient signals with growth factor dependent signaling. mTOR is organized in two independent protein complexes, mTORC1 and mTORC2. The mTORC1 complex containing mTOR, GβL/mLST8 and Raptor is sensitive to rapamycin, while the mTORC2 complex containing mTOR, GβL/mLST8, SIN1, and Rictor is rapamycin insensitive. The mTOR/Rictor complex phosphorylates numerous substrates associated with regulation of the actin cytoskeleton, and is also responsible for phosphorylation of Akt/PKB at Ser473, a critical step in Akt activation.